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Autologous and Non-U.S. Survival: Ideas for Comparative Data Sources

Posted in :: 2016 Volume 2 :: Wednesday, October 12th, 2016

Unlike allogeneic transplants in the U.S., there is no risk-adjusted report of one-year survival for autologous transplants. There are a variety of risk-adjusted survival registries around the globe, but not for every region. Yet Clinical Programs are expected to benchmark their survival to comparative data and take corrective action. One of the most common questions we receive from autologous-only or non-U.S. programs is, “Where do we find data on one-year survival for autologous transplants?”

The FACT-JACIE Hematopoietic Cell Therapy Standards do not prescribe any specific data source to use for autologous benchmarking. The following are ideas to consider:

C.W. Bill Young Cell Transplantation Program

  • S. Patient Survival Report: The U.S. Patient Survival Report displays an estimate of the number of patients who are alive after a bone marrow or umbilical cord blood transplant. The estimates are shown:
    • By disease and length of time after transplant (including one year)
    • By the type of donor who provided the cells for transplant:
      • Autologous (the patient’s cells)
      • Related allogeneic (a patient’s sibling or another family member’s cells)
      • Unrelated allogeneic (a volunteer donor’s cells)
    • The cells used for transplant (bone marrow, peripheral blood, or umbilical cord blood)

Be the Match/National Marrow Donor Program

  • Disease-Specific HCT Indications and Outcomes Data: The outcomes data presented here are based on more than 50,000 unrelated donor transplants NMDP facilitated, plus autologous and allogeneic transplant data reported to CIBMTR® (Center for International Blood and Marrow Transplant Research). This CIBMTR data and analysis are based on more than 330,000 patients from U.S. and global transplant programs.

Peer-reviewed Medical Literature

  • Scholarly articles examining multi-center one-year survival using relevant disease, donor type, and date range.